Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study

Abstract Background Genetic factors play an important role in susceptibility to methamphetamine dependency. In this line, protein that interact with C-kinase-1 (PICK1) and brain-derived neurotrophic factor ( BDNF ) genes are linked dependence (substance use disorder). Thus, a case–control study, we investigated the association between polymorphisms of PICK1 Iranian population. Methods Total 235 cases 204 controls were recruited period 2015 2018. The PICK1-rs713729 , -rs2076369 BDNF-rs6265 genotypes determined via ARMS-PCR assay. Statistical analysis was performed, using SPSS 20.0, PHASE 2.1.1 program as well SNP Analyzer 2.0. Results present two including (OR 1.38 (CI 1.08–1.52; P - value 0.004) multiplicative dominant models, PICK1-rs2076369 1.31 1.10–1.56; 0.002) multiplicative, co-dominant models associated risk abuse. Moreover, haplotype showed significant AG 2.50 1.50–4.16; 0.0002) dominant, recessive TT 0.67 0.50–0.91; 0.009) None study had high level linkage disequilibrium. Conclusion Our findings indicate gene polymorphism might affect dependency our